Neuronal current imaging of epileptic activity: An MRI study in patients with a first unprovoked epileptic seizure.

ABSTRACT:

Objective

This study evaluates the performance of the novel MRI sequence stimulus-induced rotary saturation (SIRS) to map responses to interictal epileptic activity in the human cortex. Spin-lock pulses have been applied to indirectly detect neuronal activity through magnetic field perturbations. Following initial reports about the feasibility of the method in humans and animals with epilepsy, we aimed to investigate the diagnostic yield of spin-lock MR pulses in comparison with scalp-EEG in first seizure patients.

Methods

We employed a novel method for measurements of neuronal activity through the detection of a resonant oscillating field, stimulus-induced rotary saturation contrast (SIRS) at spin-lock frequencies of 120 and 240 Hz acquired at a single 3T MRI system. Within

SUBMITTER: Jin BZ 

PROVIDER: S-EPMC11450614 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature