The hidden link between late-onset seizures and cerebral amyloid angiopathy: A case-control study.

ABSTRACT:

Objective

Epileptic seizures occurring in late adulthood often remain of unknown origin. Sporadic cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease characterized by intracerebral hemorrhage, microhemorrhage and superficial siderosis, occurring mostly in elderly. This observational case-control study aimed to assess the occurrence of CAA in patients experiencing their first seizure in late adulthood.

Methods

We enrolled consecutive patients aged ≥55 years presenting with late-onset seizures (LOS) to the emergency departments or outpatient clinics of two Italian centers, from April 2021 to October 2022. Two age-matched control subjects with neurological symptoms other than epileptic seizure were recruited for each enrolled case. All participants underwent br

SUBMITTER: Marsico O 

PROVIDER: S-EPMC11450647 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature