Increased susceptibility to kainate-induced seizures in a mouse model of tuberous sclerosis complex: Importance of sex and circadian cycle.

ABSTRACT:

Objective

Comorbidity of epilepsy and autism in tuberous sclerosis complex 2 (TSC2) is very frequent, but the link between these conditions is still poorly understood. To study neurological problems related to autism, the scientific community has been using an animal model of TSC2, Tsc2^+/- mice. However, it is still unknown whether this model has the propensity to exhibit increased seizure susceptibility. Further, the importance of sex and/or the circadian cycle in this biological process has never been addressed. This research aimed to determine whether male and female Tsc2^+/- mice have altered seizure susceptibility at light and dark phases.

Methods

We assessed seizure susceptibility and progression in a Tsc2^+/- mouse model using the chemic

SUBMITTER: Pais ML 

PROVIDER: S-EPMC11450656 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature