Easy Access to Fused Tricyclic Quinoline Derivatives through Metal-Free Electrocatalytic [4 + 2] Annulation.

ABSTRACT: An efficient electrocatalytic cycloaddition approach for the construction of a lactone- or lactam-fused quinoline framework is documented. Diverse arrays of functionalities are well-compatible under this metal-free, mild, and scalable electro-redox protocol. Mechanistic studies indicate an iodide-mediated electro-oxidation of secondary amines to their corresponding imines and consequent [4 + 2] cycloaddition, fabricating C-C bonds followed by rapid aromatization leading to the six-membered core structure.

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC11450728 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature