Metabolomic profiles of chronic distress are associated with cardiovascular disease risk and inflammation-related risk factors.

ABSTRACT:

Background

Chronic psychological distress is associated with increased risk of cardiovascular disease (CVD) and investigators have posited inflammatory factors may be centrally involved in these relationships. However, mechanistic evidence and molecular underpinnings of these processes remain unclear, and data are particularly sparse among women. This study examined if a metabolite profile linked with distress was associated with increased CVD risk and inflammation-related risk factors.

Methods

A plasma metabolite-based distress score (MDS) of twenty chronic psychological distress-related metabolites was developed in cross-sectional, 1:1 matched case-control data comprised of 558 women from the Nurses' Health Study (NHS; 279 women with distress, 279 controls). This MDS was t

SUBMITTER: Balasubramanian R 

PROVIDER: S-EPMC11450778 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature