Impact of early continuous positive airway pressure in the delivery room (DR-CPAP) on neonates < 1500 g in a low-resource setting: a protocol for a pilot feasibility and acceptability randomized controlled trial.

ABSTRACT:

Background

Preterm birth is the leading cause of childhood mortality, and respiratory distress syndrome is the predominant cause of these deaths. Early continuous positive airway pressure is effective in high-resource settings, reducing the rate of continuous positive airway pressure failure, and the need for mechanical ventilation and surfactant. However, most deaths in preterm infants occur in low-resource settings without access to mechanical ventilation or surfactant. We hypothesize that in such settings, early continuous positive airway pressure will reduce the rate of failure and therefore preterm mortality.

Methods

This is a mixed methods feasibility and acceptability, single-center pilot randomized control trial of early continuous positive airway pressure among infa

SUBMITTER: Burgoine K 

PROVIDER: S-EPMC11451038 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature