Analysis of binary mixture of oxytetracycline and bromohexine in their combined veterinary formulation by four simple spectrophotometric methods with greenness assessment.

ABSTRACT: Tetracyclines family is considered as the first-line antibiotic drugs for food animals. Formulating bromhexine (BR) with oxytetracycline (OTC) improved the antibacterial activity of OTC, besides it is considered as a mucolytic agent. Four precise, rapid, and simple spectrophotometric methods were successfully developed for resolution of the overlapped spectra of OTC and BR in their pure form and in their pharmaceutical formulation. The proposed methods are absorption correction (AC), dual wavelength (DW), induced dual wavelength (IDW), and spectrum subtraction (SS) spectrophotometric methods. The developed methods were used for the determination of OTC and BR in the ranges of 2-50 µg/mL and 1-30 µg/mL, respectively for all methods. For (AC) and (SS) methods, OTC and BR were determined at 3

SUBMITTER: Sharkawi MMZ 

PROVIDER: S-EPMC11451190 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature