Structure-function coupling in white matter uncovers the hypoconnectivity in autism spectrum disorder.

ABSTRACT:

Background

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder associated with alterations in structural and functional coupling in gray matter. However, despite the detectability and modulation of brain signals in white matter, the structure-function coupling in white matter in autism remains less explored.

Methods

In this study, we investigated structural-functional coupling in white matter (WM) regions, by integrating diffusion tensor data that contain fiber orientation information from WM tracts, with functional connectivity tensor data that reflect local functional anisotropy information. Using functional and diffusion magnetic resonance images, we analyzed a cohort of 89 ASD and 63 typically developing (TD) individuals from the Autism Brain Imaging Data Exc

SUBMITTER: Qing P 

PROVIDER: S-EPMC11451199 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature