Adaptive designs in clinical trials: a systematic review-part I.

ABSTRACT:

Background

Adaptive designs (ADs) are intended to make clinical trials more flexible, offering efficiency and potentially cost-saving benefits. Despite a large number of statistical methods in the literature on different adaptations to trials, the characteristics, advantages and limitations of such designs remain unfamiliar to large parts of the clinical and research community. This systematic review provides an overview of the use of ADs in published clinical trials (Part I). A follow-up (Part II) will compare the application of AD in trials in adult and pediatric studies, to provide real-world examples and recommendations for the child health community.

Methods

Published studies from 2010 to April 2020 were searched in the following databases: MEDLINE (Ovid), Embase (Ovid)

SUBMITTER: Ben-Eltriki M 

PROVIDER: S-EPMC11451232 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature