Dihydroartemisinin suppresses the susceptibility of Anopheles stephensi to Plasmodium yoelii by activating the Toll signaling pathway.

ABSTRACT:

Background

Malaria is a serious public health concern. Artemisinin and its derivatives are first-line drugs for the treatment of Plasmodium falciparum malaria. In mammals, artemisinin exhibits potent anti-inflammatory and immunoregulatory properties. However, it is unclear whether artemisinin plays a regulatory role in the innate immunity of mosquitoes, thereby affecting the development of Plasmodium in Anopheles when artemisinin and its metabolites enter mosquitoes. This study aims to determine the effect of dihydroartemisinin (DHA), a first-generation semisynthetic derivative of artemisinin, on innate immunity and malaria vector competence of Anopheles stephensi.

Methods

Anopheles stephensi was fed Plasmodium-infected mice treated with DHA via gavage, Plasmodium-infected b

SUBMITTER: Liu T 

PROVIDER: S-EPMC11451267 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature