Sex-specific post-inflammatory dysbiosis mediates chronic visceral pain in colitis.

ABSTRACT:

Background

Despite achieving endoscopic remission, over 20% of inflammatory bowel disease (IBD) patients experience chronic abdominal pain. Visceral pain and the microbiome exhibit sex-dependent interactions, while visceral pain in IBD shows a sex bias. Our aim was to evaluate whether post-inflammatory microbial perturbations contribute to visceral hypersensitivity in a sex-dependent manner.

Methods

Males, cycling females, ovariectomized, and sham-operated females were given dextran sodium sulfate to induce colitis and allowed to recover. Germ-free recipients received sex-appropriate and cross-sex fecal microbial transplants (FMT) from post-inflammatory donor mice. Visceral sensitivity was assessed by recording visceromotor responses to colorectal distention. The composition

SUBMITTER: Arzamendi MJ 

PROVIDER: S-EPMC11451282 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature