Heterogeneity Analysis on Multi-state Brain Functional Connectivity and Adolescent Neurocognition.

ABSTRACT: Brain functional connectivity or connectome, a unique measure for brain functional organization, provides a great potential to explain the neurobiological underpinning of behavioral profiles. Existing connectome-based analyses highly concentrate on brain activities under a single cognitive state, and fail to consider heterogeneity when attempting to characterize brain-to-behavior relationships. In this work, we study the complex impact of multi-state functional connectivity on behaviors by analyzing the data from a recent landmark brain development and child health study. We propose a nonparametric, Bayesian supervised heterogeneity analysis to uncover neurodevelopmental subtypes with distinct effect mechanisms. We impose stochastic block structures to identify network-based functional phe

SUBMITTER: Wang S 

PROVIDER: S-EPMC11451334 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature