Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-a-go-go-related gene) K⁺ channel subunits.

ABSTRACT: Potassium channels stabilize the resting potential and neuronal excitability. Among them, erg (ether-à-go-go-related gene) K⁺ channels represent a subfamily of voltage-gated channels, consisting of erg1, erg2, and erg3 subunits; however, their subunit-specific neuronal functions in vivo are barely understood. To find erg3- and erg1-mediated functions, we generated global Kcnh7 (erg3) and conditional Kcnh2 (erg1) knockout mice. We found that erg3 channels stabilize the resting potential and dampen spontaneous activity in cerebellar Purkinje cells (PCs) and hippocampal CA1 neurons, whereas erg1 channels have suprathreshold functions. Lack of erg3 subunits induced hyperexcitability with increased action potential firing in PCs, but not in CA1 neurons. No

SUBMITTER: Schwarz JR 

PROVIDER: S-EPMC11451553 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature