Biologically-informed Killer cell immunoglobulin-like receptor (KIR) gene annotation tool.

ABSTRACT: Natural killer (NK) cells are essential components of the innate immune system, with their activity significantly regulated by Killer cell Immunoglobulin-like Receptors (KIRs). The diversity and structural complexity of KIR genes present significant challenges for accurate genotyping, essential for understanding NK cell functions and their implications in health and disease. Traditional genotyping methods struggle with the variable nature of KIR genes, leading to inaccuracies that can impede immunogenetic research. These challenges extend to high-quality phased assemblies, which have been recently popularized by the Human Pangenome Consortium. This paper introduces BAKIR (Biologically-informed Annotator for KIR locus), a tailored computational tool designed to overcome the challenges of KI

SUBMITTER: Ford MKB 

PROVIDER: S-EPMC11451589 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature