Systemic identification of functionally conserved lncRNA metabolic regulators in human and mouse livers.

ABSTRACT:

Background & aims

Unlike protein-coding genes, the majority of human long non-coding RNAs (lncRNAs) lack conservation based on their sequences, posing a challenge for investigating their role in a pathophysiological context for clinical translation. This study explores the hypothesis that non-conserved lncRNAs in human and mouse livers may share similar metabolic functions, giving rise to functionally conserved lncRNA metabolic regulators (fcLMRs).

Methods

We developed a sequence-independent strategy to select putative fcLMRs, and performed extensive analysis to determine the functional similarities of putative human and mouse LMR pairs (h/mLMRs).

Results

We found that several pairs of putative fcLMRs share similar functions in regulating gene expression. We further d

SUBMITTER: Jiang C 

PROVIDER: S-EPMC11451612 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature