Assessment of common genetic variation in Alzheimer's and Parkinson's diseases reveals global distinction in population attributable risk.

ABSTRACT: Emerging evidence suggests that the genetic architecture of Alzheimer's (AD) and Parkinson's diseases (PD) risk varies across ancestries. This study seeks to explore distinct and universal genetic targets across individuals of Latino, African/African Admixed, East Asian, and European populations by implementing Population Attributable Risk (PAR) comparisons on summary statistics from genome-wide association studies (GWAS). PAR was calculated for the most significant disease variants using summary statistics derived from select multi-ancestry GWAS meta-analyses, followed by fine-mapping analysis to validate genetic contribution of disease variants to European, African/African Admixed, East Asian, and Latino individuals. For both AD, APOE4 PAR estimates were universally high across al

SUBMITTER: Jones L 

PROVIDER: S-EPMC11451675 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature