No Increased Risk of Major Adverse Cardiovascular Events following Nicotinamide Exposure.

ABSTRACT:

Importance

Nicotinamide metabolites have recently been implicated in increased risk of major cardiovascular events (MACE). Supportive data about clinical risk of MACE for nicotinamide users is lacking.

Objective

To determine whether nicotinamide use results in an increase of MACE.

Design setting participants

Retrospective cohort study of two patient cohorts, Vanderbilt University Medical Center (VUMC) and Military Veteran Program (MVP). The risk of MACE in patients exposed to nicotinamide was compared to the risk of MACE in unexposed patients. In the VUMC cohort, 1228 patients were exposed to nicotinamide based on keyword entry for "nicotinamide" or "niacinamide" and hand-review of charts, while 253 were unexposed but had documented recommendation for use. In the MVP

SUBMITTER: Wheless L 

PROVIDER: S-EPMC11451707 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature