Genomic Surveillance for Enhanced Healthcare Outbreak Detection and Control.

ABSTRACT:

Background

Current methods are insufficient alone for outbreak detection in hospitals. Real-time genomic surveillance using offers the potential to detect otherwise unidentified outbreaks. We initiated and evaluated the Enhanced Detection System for Healthcare-associated Transmission (EDS-HAT), a real-time genomic surveillance program for outbreak detection and mitigation.

Methods

This study was conducted at UPMC Presbyterian Hospital from November 2021 to October 2023. Whole genome sequencing (WGS) was performed weekly on healthcare-associated clinical bacterial isolates to identify otherwise undetected outbreaks. Interventions were implemented in real-time based on identified transmission. A clinical and economic impact analysis was conducted to estimate infections averted

SUBMITTER: Sundermann AJ 

PROVIDER: S-EPMC11451765 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature