Paramagnetic Rim Lesions are Highly Specific for Multiple Sclerosis in Real-World Data.

ABSTRACT:

Background

Paramagnetic rim lesions (PRL) are an emerging biomarker for multiple sclerosis (MS). In addition to associating with greater disease severity, PRL may be diagnostically supportive.

Objective

Our aim was to determine PRL specificity and sensitivity for discriminating MS from its diagnostic mimics using real-world clinical diagnostic and imaging data.

Methods

This is a retrospective, cross-sectional analysis of a longitudinal cohort of patients with prospectively collected observational data. Patients were included if they underwent neuroimmunological evaluation in our academic MS center, and had an available MRI scan from the same clinical 3T magnet that included a T2*-weighted sequence with susceptibility postprocessing (SWAN protocol, GE). SWAN-derived fi

SUBMITTER: Hemond CC 

PROVIDER: S-EPMC11451766 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature