DNA methylation age acceleration is associated with incident cognitive impairment in the Health and Retirement Study.

ABSTRACT:

Background

DNA methylation clocks have emerged as promising biomarkers for cognitive impairment and dementia. Longitudinal studies exploring the link between DNA methylation clocks and cognitive decline have been constrained by limited sample sizes and a lack of diversity.

Objective

Our study aimed to investigate the longitudinal associations between DNA methylation clocks and incident cognitive impairment using a larger sample size encompassing a US nationally representative sample from the Health and Retirement Study.

Methods

We measured DNA methylation age acceleration in 2016 by comparing the residuals of DNA methylation clocks, including GrimAge, against chronological age. Cognitive decline was determined by the change in Langa-Weir cognition status from 2016 to

SUBMITTER: Blostein F 

PROVIDER: S-EPMC11451769 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature