Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes.

ABSTRACT:

Background

The purpose of this work was to characterize the expression of drug and nutrient carriers along the anterior-posterior and crypt-villus axes of the intestinal epithelium and to study the validity of utilizing whole gut tissue rather than purified epithelial cells to examine regional variations in gene expression.

Results

We have characterized the mRNA expression profiles of 76 % of all currently known transporters along the anterior-posterior axis of the gut. This is the first study to describe the expression profiles of the majority of all known transporters in the intestine. The expression profiles of transporters, as defined according to the Gene Ontology consortium, were measured in whole tissue of the murine duodenum, jejunum, ileum and colon using high-densi

SUBMITTER: Anderle P 

PROVIDER: S-EPMC1145182 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature