Current opinion: antiretrovirals during pregnancy and breastfeeding.

ABSTRACT:

Purpose of review

To review the most important literature from the past 2 years on the pharmacokinetics of antiretrovirals in pregnancy, placental transfer, and breastmilk.

Recent findings

Concentrations of antiretrovirals frequently used in pregnancy and their placental transfer are described, together with infant exposure through breastmilk. Also, applications of ex-vivo and in-silico studies, such as placenta perfusion studies and PBPK models, are discussed.

Summary

Great efforts were made in the past 2 years to accelerate the availability of data on antiretrovirals during pregnancy and lactation. Bictegravir showed decreased but still sufficient concentrations during pregnancy, leading to a label change by the FDA. In-silico and clinical studies on long-acting cab

SUBMITTER: Nijboer L 

PROVIDER: S-EPMC11451929 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature