Strong in vitro anticancer activity of copper(ii) and zinc(ii) complexes containing naturally occurring lapachol: cellular effects in ovarian A2780 cells.

ABSTRACT: Copper(ii) and zinc(ii) complexes with lapachol (HLap) of the composition [M(Lap)₂(N-N)] and [Cu(Lap)(H₂O)(terpy)]NO₃ (4), where M = Cu (1-3) or Zn (for 5-7), and N-N stands for bathophenanthroline (1 and 5), 5-methyl-1,10-phenanthroline (2 and 6), 2,2'-bipyridine (3), 2,2';6',2''-terpyridine (terpy, 4) and 1,10-phenanthroline (7), were synthesised and characterised. Complexes 1-5 revealed strong in vitro antiproliferative effects against A2780, A2780R, MCF-7, PC-3, A549 and HOS human cancer lines and MRC-5 normal cells, with IC₅₀ values above 0.5 μM, and reasonable selectivity index (SI), with SI > 3.8 for IC₅₀(MRC-5)/IC₅₀(A2780). Considerable time-dependent cytotoxicity in A2780 cells was observed for complexes 6 an

SUBMITTER: Stocchetti S 

PROVIDER: S-EPMC11451940 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature