The components of arginine and methylarginine metabolism are indicative of altered kidney function in intrauterine growth-restricted neonates.

ABSTRACT:

Background

Intrauterine fetal growth restriction (IUGR) affects up to 10% of all pregnancies. Severe IUGR is associated with impaired kidney development, reduced nephron endowment, and chronic kidney disease later in life. Currently, no early predictive biomarker exists for detecting altered kidney function in neonates with IUGR. Because nephrons produce key enzymes for the metabolism of arginine and methylarginine components, we quantified and compared the concentrations of arginine and methylarginine metabolites between IUGR and non-IUGR neonates to identify potential biomarkers for the early detection of altered kidney function in IUGR neonates.

Methods

Seventy-one IUGR and 123 non IUGR neonates were examined. Serum and Urine samples were obtained between 30 h and 5 days

SUBMITTER: Kleinebenne L 

PROVIDER: S-EPMC11451945 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature