Utility of Axillary Staging in Older Patients with HER2-Positive Breast Cancer.

ABSTRACT:

Background

The utility of sentinel lymph node biopsy (SLNB) in older patients remains controversial. Advancements in human epidermal growth factor receptor 2 (HER2)-directed therapy have revolutionized disease response rates and prognosis, supporting efforts to re-evaluate the utility of SLNB. We aimed to assess the differences in treatment and overall survival (OS) in older patients with HER2-positive breast cancer based on SLNB.

Methods

Using the National Cancer Database (2010-2020), patients ≥ 70 years of age diagnosed with cT1-2/cN0/M0, HER2-positive breast cancer were identified. Logistic regression assessed associations with SLNB, systemic therapy, and radiation. Cox proportional hazard models were used to identify factors associated with OS. Analyses were stratified b

SUBMITTER: Dalton JC 

PROVIDER: S-EPMC11452275 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature