Structure prediction analysis of human core TIM23 complex reveals conservation of the protein translocation mechanism.

ABSTRACT: The majority of mitochondrial proteins are encoded in the nucleus, translated on cytosolic ribosomes, and subsequently targeted to the mitochondrial surface. Their further import into the organelle is facilitated by highly specialized protein translocases. Mitochondrial precursor proteins that are destined to the mitochondrial matrix and, to some extent, the inner membrane, utilize translocase of the inner membrane (TIM23). This indispensable import machinery has been extensively studied in yeast. The translocating unit of the TIM23 complex in yeast consists of two membrane proteins, Tim17 and Tim23. In contrast to previous findings, recent reports demonstrate the primary role of Tim17, rather than Tim23, in the translocation of newly synthesized proteins. Very little is known about human

SUBMITTER: Maruszczak KK 

PROVIDER: S-EPMC11452300 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature