Daily rhythms in metabolic and locomotor behaviour of prematurely ageing PolgA mice.

ABSTRACT: Ageing is an inherent and intricate biological process that takes place in living organisms as time progresses. It involves the decline of multiple physiological functions, leading to body structure and overall performance modifications. The ageing process differs among individuals and is influenced by various factors, including lifestyle, environment and genetic makeup. Metabolic changes and reduced locomotor activity are common hallmarks of ageing. Our study focuses on exploring these phenomena in prematurely ageing PolgA^{(D257A/D257A)} mice (also known as PolgA) aged 41-42 weeks, as they closely mimic human ageing. We assess parameters such as oxygen consumption (VO₂), carbon dioxide production (VCO₂), respiratory exchange ratio (RER) and locomotor activit

SUBMITTER: Singh A 

PROVIDER: S-EPMC11452303 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature