Deep-learning based discrimination of pathologic complete response using MRI in HER2-positive and triple-negative breast cancer.

ABSTRACT: Distinguishing between pathologic complete response and residual cancer after neoadjuvant chemotherapy (NAC) is crucial for treatment decisions, but the current imaging methods face challenges. To address this, we developed deep-learning models using post-NAC dynamic contrast-enhanced MRI and clinical data. A total of 852 women with human epidermal growth factor receptor 2 (HER2)-positive or triple-negative breast cancer were randomly divided into a training set (n = 724) and a validation set (n = 128). A 3D convolutional neural network model was trained on the training set and validated independently. The main models were developed using cropped MRI images, but models using uncropped whole images were also explored. The delayed-phase model demonstrated superior performance compared to the

SUBMITTER: Kim SY 

PROVIDER: S-EPMC11452398 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature