AAV-mouse DNase I sustains long-term DNase I expression in vivo and suppresses breast cancer metastasis.

ABSTRACT: Neutrophil extracellular traps (NETs) have been implicated in the pathology of various inflammatory conditions. In cancer, NETs have been demonstrated to induce systemic inflammation, impair peripheral vessel and organ function and promote metastasis. Here we show that the plasma level of NETs is significantly higher in patients with metastatic breast cancer compared to those with local disease, or those that were considered cured at a 5-year follow-up, confirming NETs as interesting therapeutic targets in metastatic breast cancer. Administration of DNase I is one strategy to eliminate NETs but long-term treatment requires repeated injections and species-specific versions of the enzyme. To enhance administration and therapeutic efficacy, we have developed an adeno-associated virus (AAV) ve

SUBMITTER: Herre M 

PROVIDER: S-EPMC11452440 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature