Cholesterol promotes <i>IFNG</i> mRNA expression in CD4⁺ effector/memory cells by SGK1 activation.

ABSTRACT: IFNγ-secreting T cells are central for the maintenance of immune surveillance within the central nervous system (CNS). It was previously reported in healthy donors that the T-cell environment in the CNS induces distinct signatures related to cytotoxic capacity, CNS trafficking, tissue adaptation, and lipid homeostasis. These findings suggested that the CNS milieu consisting predominantly of lipids mediated the metabolic conditions leading to IFNγ-secreting brain CD4 T cells. Here, we demonstrate that the supplementation of CD4⁺CD45RO⁺CXCR3⁺ cells with cholesterol modulates their function and increases IFNG expression. The heightened IFNG expression was mediated by the activation of the serum/glucocorticoid-regulated kinase (SGK1). Inhibition o

SUBMITTER: Hanin A 

PROVIDER: S-EPMC11452476 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature