Deciphering autism heterogeneity: a molecular stratification approach in four mouse models.

ABSTRACT: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impairments in social interaction and communication, as well as restrained or stereotyped behaviors. The inherent heterogeneity within the autism spectrum poses challenges for developing effective pharmacological treatments targeting core features. Successful clinical trials require the identification of robust markers to enable patient stratification. In this study, we identified molecular markers within the oxytocin and immediate early gene families across five interconnected brain structures of the social circuit. We used wild-type and four heterogeneous mouse models, each exhibiting unique autism-like behaviors modeling the autism spectrum. While dysregulations in the oxytocin family were model-sp

SUBMITTER: Gora C 

PROVIDER: S-EPMC11452541 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature