High androgen level during controlled ovarian stimulation cycle impairs endometrial receptivity in PCOS patients.

ABSTRACT: PCOS is one of the most common endocrine disorders among women of reproductive age. While the mechanism involved is not yet fully characterized. Our study aims to examine the pregnancy outcomes of embryo transfers in women with PCOS after pretreatment, and to explore the possible effect of high androgen levels on endometrial receptivity. Retrospective cohort study was conducted to analyze pregnancy outcomes among 2714 infertile women with tubal factor and 452 PCOS women. Endometrium samples were collected from 6 controls and 6 PCOS patients to detect the expression of endometrial receptivity marks. The implantation rate, clinical and ongoing pregnancy rates and live birth rate in women with PCOS followed fresh embryo transfers were obviously decreased even after the pretreatment. Similar p

SUBMITTER: Wei SY 

PROVIDER: S-EPMC11452613 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature