Profiling muscle transcriptome in mice exposed to microgravity using gene set enrichment analysis.

ABSTRACT: Space exploration's advancement toward long-duration missions prompts intensified research on physiological effects. Despite adaptive physiological stability in some variables, persistent changes affect genome integrity, immune response, and cognitive function. Our study, utilizing multi-omics data from GeneLab, provides crucial insights investigating muscle atrophy during space mission. Leveraging NASA GeneLab's data resources, we apply systems biology-based analyses, facilitating comprehensive understanding and enabling meta-analysis. Through transcriptomics, we establish a reference profile of biological processes underlying muscle atrophy, crucial for intervention development. We emphasize the often-overlooked role of glycosylation in muscle atrophy. Our research sheds light on fundame

SUBMITTER: Oommen AM 

PROVIDER: S-EPMC11452717 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature