Association of Baseline Depression and Anxiety with Longitudinal Health Outcomes in Parkinson's Disease.

ABSTRACT:

Background

Anxiety and depression are common non-motor symptoms in Parkinson's disease (PD) but remain under-recognized and under-treated.

Objectives

To evaluate functional outcomes associated with baseline anxiety or depression and effects related to the initiation of new psychiatric treatment.

Methods

We analyzed 7 years of data from patients with de novo PD enrolled in the Parkinson's Progression Markers Initiative. Longitudinal regression models evaluated the association between baseline anxiety and depression with Schwab and England (SE) and MDS-UPDRS total scores over time. Cox proportional hazard models assessed effects of baseline anxiety and depression on time to initiation of dopaminergic therapy. Piecewise linear regression models examined the association o

SUBMITTER: Shi Y 

PROVIDER: S-EPMC11452785 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature