Dopa Responsiveness in Parkinson's Disease.

ABSTRACT:

Background

Dopaminergic responsiveness is a defining feature of Parkinson's disease (PD). However, there is limited information on how this evolves over time.

Objectives

To examine serial dopaminergic responses, if there are distinct patterns, and which factors predict these.

Methods

We analyzed data from the Parkinson's Progression Markers Initiative on repeated dopaminergic challenge tests (≥24.5% defined as a definite response). Growth-mixture modeling evaluated for different response patterns and multinomial logistic regression tested for predictors of these clusters.

Results

1525 dopaminergic challenge tests were performed in 336 patients. At enrolment, mean age was 61.2 years (SD 9.6), 66.4% were male and disease duration was 0.5 years (SD 0.5). 1 to 2 ye

SUBMITTER: Gandhi SE 

PROVIDER: S-EPMC11452786 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature