Urine eosinophil-derived neurotoxin: A potential marker of activity in select eosinophilic disorders.

ABSTRACT:

Background

Biomarkers of eosinophilic disease activity, especially in the context of novel therapies that reduce blood eosinophil counts, are an unmet need. Absolute eosinophil count (AEC) does not accurately reflect tissue eosinophilia or eosinophil activation. Therefore, the aims of this study were to compare the reliability of plasma and urine eosinophil major basic protein 1, eosinophil cationic protein, eosinophil-derived neurotoxin (EDN), and eosinophil peroxidase measurement and to evaluate the usefulness of eosinophil granule protein (EGP) measurement for the assessment of disease activity in patients with eosinophil-associated diseases treated with mepolizumab, benralizumab, or dexpramipexole.

Methods

Eosinophil granule protein concentrations were measured in serum,

SUBMITTER: Makiya MA 

PROVIDER: S-EPMC11452843 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature