Long-term effects of vagus nerve stimulation on EEG aperiodic components in patients with drug-resistant epilepsy.

ABSTRACT:

Background

Drug-resistant epilepsy (DRE) affects approximately one-third of epilepsy patients who do not achieve adequate seizure control with medication. Vagus nerve stimulation (VNS) is an adjunctive therapy for DRE, but its long-term effects on cortical excitability remain unclear.

Objectives

This study aims to elucidate the long-term effects of VNS on electroencephalography (EEG) aperiodic components in patients with DRE. Our objective is to identify biomarkers that can serve as indicators of therapeutic efficacy and provide mechanistic insights into the underlying neural processes.

Design

This longitudinal observational study focused on patients with DRE undergoing VNS therapy at Sanbo Brain Hospital. The reduction in seizure frequency rates was quantified over s

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11452897 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature