Low-intensity focused ultrasound to the posterior insula reduces temporal summation of pain.

ABSTRACT:

Background

The insula and dorsal anterior cingulate cortex (dACC) are core brain regions involved in pain processing and central sensitization, a shared mechanism across various chronic pain conditions. Methods to modulate these regions may serve to reduce central sensitization, though it is unclear which target may be most efficacious for different measures of central sensitization.

Objective/hypothesis

Investigate the effect of low-intensity focused ultrasound (LIFU) to the anterior insula (AI), posterior insula (PI), or dACC on conditioned pain modulation (CPM) and temporal summation of pain (TSP).

Methods

N = 16 volunteers underwent TSP and CPM pain tasks pre/post a 10 min LIFU intervention to either the AI, PI, dACC or Sham stimulation. Pain ratings were collecte

SUBMITTER: In A 

PROVIDER: S-EPMC11452899 | biostudies-literature | 2024 Jul-Aug

REPOSITORIES: biostudies-literature