Terminal differentiation precedes functional circuit integration in the peduncle neurons in regenerating Hydra vulgaris.

ABSTRACT: Understanding how neural circuits are regenerated following injury is a fundamental question in neuroscience. Hydra is a powerful model for studying this process because it has a simple neural circuit structure, significant and reproducible regenerative abilities, and established methods for creating transgenics with cell-type-specific expression. While Hydra is a long-standing model for regeneration and development, little is known about how neural activity and behavior is restored following significant injury. In this study, we ask if regenerating neurons terminally differentiate prior to reforming functional neural circuits, or if neural circuits regenerate first and then guide the constituent naive cells toward their terminal fate. To address this question, we developed a dual-expressi

SUBMITTER: Escobar A 

PROVIDER: S-EPMC11452936 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature