Targeting CD276 for T cell-based immunotherapy of breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is the most common malignancy in women. Immunotherapy has revolutionized treatment options in many malignancies, and the introduction of immune checkpoint inhibition yielded beneficial results also in BC. However, many BC patients are ineligible for this T cell-based therapy, others do not respond or only briefly. Thus, there remains a high medical need for new therapies, particularly for triple-negative BC. CD276 (B7-H3) is overexpressed in several tumors on both tumor cells and tumor vessels, constituting a promising target for immunotherapy.

Methods

We analyzed tumor samples of 25 patients using immunohistochemistry to assess CD276 levels. The potential of CC-3, a novel bispecific CD276xCD3 antibody, for BC treatment was evaluated using vario

SUBMITTER: Hagelstein I 

PROVIDER: S-EPMC11452943 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature