Ozone therapy mitigates parthanatos after ischemic stroke.

ABSTRACT:

Background

Stroke is a leading cause of death worldwide, with oxidative stress and calcium overload playing significant roles in the pathophysiology of the disease. Ozone, renowned for its potent antioxidant properties, is commonly employed as an adjuvant therapy in clinical settings. Nevertheless, it remains unclear whether ozone therapy on parthanatos in cerebral ischemia-reperfusion injury (CIRI). This study aims to investigate the impact of ozone therapy on reducing parthanatos during CIRI and to elucidate the underlying mechanism.

Methods

Hydrogen peroxide (H₂O₂) was utilized to mimic the generation of reactive oxygen species (ROS) in SH-SY5Y cell reperfusion injury in vitro, and an in vivo ischemic stroke model was established. Ozone saline was in

SUBMITTER: Li J 

PROVIDER: S-EPMC11453019 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature