The goat pan-genome reveals patterns of gene loss during domestication.

ABSTRACT:

Background

Unveiling genetic diversity features and understanding the genetic mechanisms of diverse goat phenotypes are pivotal in facilitating the preservation and utilization of these genetic resources. However, the total genetic diversity within a species can't be captured by the reference genome of a single individual. The pan-genome is a collection of all the DNA sequences that occur in a species, and it is expected to capture the total genomic diversity of the specific species.

Results

We constructed a goat pan-genome using map-to-pan assemble based on 813 individuals, including 723 domestic goats and 90 samples from their wild relatives, which presented a broad regional and global representation. In total, 146 Mb sequences and 974 genes were identified as absent from

SUBMITTER: Liu J 

PROVIDER: S-EPMC11453020 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature