Dynamic BMP signaling mediates notochord segmentation in zebrafish.

ABSTRACT: The vertebrate spine is a metameric structure composed of alternating vertebral bodies (centra) and intervertebral discs.¹ Recent studies in zebrafish have shown that the epithelial sheath surrounding the notochord differentiates into alternating cartilage-like (col2a1/col9a2+) and mineralizing (entpd5a+) segments which serve as a blueprint for centra formation.^2,3,4,5 This process also defines the trajectories of migrating sclerotomal cells that form the mature vertebral bodies.⁴ Previous work demonstrated that notochord segmentation is typically sequential and involves the segmented activation of Notch signaling.² However, it is unclear how Notch is activated in an alternating an

SUBMITTER: Peskin B 

PROVIDER: S-EPMC11455448 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature