Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion.

ABSTRACT:

Introduction

Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown.

Objectives/methods

This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort.

Results

Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period.

Conclusion

This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO

SUBMITTER: Ong MLY 

PROVIDER: S-EPMC11455687 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature