Mediating role of accelerated aging in the association between depression and mortality risk: findings from NHANES.

ABSTRACT:

Objective

To investigate the association between depression, accelerated biological aging, and mortality risk, and to assess whether accelerated aging mediates the relationship between major depression and mortality risk.

Methods

A prospective cohort of 12,761 participants aged 20 years or older from the 2005-2010 cycle of the National Health and Nutrition Examination Survey (NHANES) was analyzed. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), with scores of ≥ 10 indicating major depression. Accelerated biological aging was measured using phenotypic age acceleration (PhenoAgeAccel). Multivariable linear regression models and subgroup analyses were used to examine the association between depression and accelerated aging, while weighted multivariable

SUBMITTER: Xu C 

PROVIDER: S-EPMC11455804 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature