Effect of Chronic Dolutegravir Administration on the Trace Amine Profile in Wistar Rats.

ABSTRACT:

Background

Dolutegravir (DTG), an integrase strand inhibitor, is currently used as the first-line treatment for HIV. Despite relatively poor tissue penetration, the risk of adverse effects in metabolic and excretory systems should be considered. The trace aminergic system and trace amines are emerging as relevant role players in many chronic diseases that are commonly diagnosed but poorly understood. Trace amines are biogenic amines that are endogenously produced and can also be ingested by the intake of trace amine-rich food. Trace amines are known to differentially regulate inflammatory and neurological outcome.

Objective

This study investigated the effects of DTG on the trace amine profile in a wistar rat model.

Methods

A total of 24 healthy wistar rats were random

SUBMITTER: Henning N 

PROVIDER: S-EPMC11455829 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature