To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants.

ABSTRACT: In the era of renewed space exploration, comprehending the effects of the space environment on human health, particularly for deep space missions, is crucial. While extensive research exists on the impacts of spaceflight, there is a gap regarding female reproductive risks. We hypothesize that space stressors could have enduring effects on female health, potentially increasing risks for future pregnancies upon return to Earth, particularly related to small-for-gestational-age (SGA) fetuses. To address this, we identify a shared microRNA (miRNA) signature between SGA and the space environment, conserved across humans and mice. These miRNAs target genes and pathways relevant to diseases and development. Employing a machine learning approach, we identify potential FDA-approved drugs to mitigat

SUBMITTER: Corti G 

PROVIDER: S-EPMC11455966 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature