Morphology of the normative human cone photoreceptor mosaic and a publicly available adaptive optics montage repository.

ABSTRACT: Adaptive optics ophthalmoscopy has enabled visualization of the in vivo human photoreceptor mosaic in health, disease and its treatment. Despite this, the clinical utility of the imaging technology has been limited by a lack of automated analysis techniques capable of accurately quantifying photoreceptor structure and a lack of an available normative image database. Here, we present a fully automated algorithm for estimating cone spacing and density over a complete adaptive optics montage along with a database of normative images and cone densities. We imaged the cone mosaics surrounding the fovea and along the horizontal and vertical meridians of fifty normal-sighted controls with a custom-built, multimodal adaptive optics scanning light ophthalmoscope. Cone spacing was automatically meas

SUBMITTER: Cooper RF 

PROVIDER: S-EPMC11455974 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature