Melatonin Bioavailability After Oral Administration of a New Delayed-Release Form in Healthy Male Volunteers.

ABSTRACT:

Background

Two main types of galenic formulation, immediate release and prolonged release, have been developed to optimize melatonin bioavailability. We recently described the kinetic profile of a prolonged-release form generating a peak of plasma melatonin 1 h (T_max) after intake, followed by a prolonged decay over time. We have developed a new oral form of melatonin with the aim of producing a melatonin peak several hours after intake.

Objective

The objective is to investigate melatonin bioavailability after administration of this new delayed-release form (DR form).

Methods

In this single-centre open-label study, 12 healthy male volunteers received one tablet of the DR form containing 1.9 mg melatonin, 10 mg zinc and 200 mg lemon balm extract (Melissa off

SUBMITTER: Ait Abdellah S 

PROVIDER: S-EPMC11456059 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature