Serum and Fecal Metabolite Profiles Linking With Gut Microbiome in Triple-Negative Breast Cancer Patients.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by poor prognosis due to the absence of effective targeted therapies. Emerging evidence indicates that the gut microbiota and its metabolites play a key role in the occurrence and development of TNBC. This study aimed to explore the metabolic changes and potential mechanisms associated with TNBC.

Objectives

This study aimed to explore the potential relationship between targeted metabolites and the gut microbiota in TNBC.

Design

We recruited 8 participants, including 4 with TNBC and 4 with benign fibroadenomas as controls.

Methods

The gut microbiota was analyzed using metagenomics on fecal samples. Liquid chromatography-mass spectrometry (LC-MS) was employed to identify d

SUBMITTER: Liu J 

PROVIDER: S-EPMC11456214 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature